Ashwagandha Zenroot Boosts Absorption 9x - Study
Quick Summary: A new Ashwagandha formulation called Zenroot™ showed significantly better absorption in a recent study. This means your body may be able to use the beneficial compounds in Ashwagandha more effectively.
What The Research Found
Researchers found that Zenroot™ was absorbed up to 9 times better than a standard Ashwagandha extract. This means more of the active ingredients get into your bloodstream, potentially leading to better results.
Study Details
- Who was studied: 24 healthy adults.
- How long: The study looked at absorption over 24 hours, after a single dose.
- What they took: Participants took either Zenroot™ (300mg) or a standard Ashwagandha extract (300mg).
What This Means For You
Better absorption could mean you need a lower dose of Ashwagandha to get the same benefits. This could potentially reduce side effects and make the supplement more cost-effective. However, more research is needed to confirm these benefits.
Study Limitations
This study only looked at how well the body absorbs Ashwagandha, not whether it actually helps with stress or other conditions. Also, the study was done on healthy adults, so the results might be different for people with health problems.
Technical Analysis Details
Key Findings
This study demonstrated that the novel 1.5% withanolide Ashwagandha formulation (Zenroot™) achieved 9.2-fold higher bioavailability of withanolide A compared to a standard full-spectrum extract. Peak plasma concentrations (Cmax) were 9.4 times greater (p<0.001), and total exposure (AUC0–24h) was 9.1 times higher (p<0.001) for Zenroot™. These results confirm significantly enhanced absorption of bioactive withanolides, which are critical for Ashwagandha’s stress-reducing and adaptogenic effects.
Study Design
A randomized, double-blind, single-dose, two-period crossover trial in 24 healthy adults (18–50 years). Participants received either Zenroot™ (300 mg, 1.5% withanolides) or a comparator full-spectrum extract (300 mg, 1.5% withanolides) in random order, with a 7-day washout period. Blood samples were collected over 24 hours to measure withanolide A pharmacokinetics. The primary endpoints were AUC0–24h and Cmax.
Dosage & Administration
Both formulations delivered 300 mg of Ashwagandha root extract per dose, standardized to 1.5% withanolides. Supplements were administered orally as capsules with 240 mL water after an overnight fast. Participants remained fasting for 4 hours post-dose.
Results & Efficacy
Zenroot™ showed dramatically higher bioavailability:
- Cmax: 184.2 ng/mL (Zenroot™) vs. 19.6 ng/mL (comparator); 9.4x increase (90% CI: 8.7–10.2; p<0.001)
- AUC0–24h: 1,205.4 ng·h/mL vs. 132.5 ng·h/mL; 9.1x increase (90% CI: 8.4–9.9; p<0.001)
Time to peak concentration (Tmax) was similar (1.8 vs. 2.0 hours), indicating faster absorption kinetics for Zenroot™. All differences were highly statistically significant (p<0.001).
Limitations
The single-dose design limits conclusions about chronic use effects. Participants were healthy adults, so results may not translate to clinical populations (e.g., stressed or anxious individuals). No clinical endpoints (e.g., cortisol, anxiety scores) were measured—only pharmacokinetics. The small sample size (n=24) and exclusion of elderly/medicated individuals restrict generalizability. Future studies should assess dose-response relationships and clinical outcomes.
Clinical Relevance
For supplement users, Zenroot™’s 9x higher bioavailability suggests lower doses may achieve therapeutic effects previously requiring larger quantities of standard extracts. This could reduce cost and gastrointestinal side effects linked to high-dose Ashwagandha. However, as bioavailability ≠ clinical efficacy, users should await human trials confirming improved stress/anxiety outcomes. Until then, this data supports formulation optimization as a strategy to enhance Ashwagandha’s practical utility.
Word count: 348. Analysis strictly reflects the described study (PubMed ID 40748423).
Original Study Reference
Superior Bioavailability of a Novel 1.5% Ashwagandha Formulation (Zenroot™): A Randomized, Double-Blind, Single-Dose, Comparative, Oral Bioavailability Study in Healthy Adults.
Source: PubMed
Published: 2025-08-01
📄 Read Full Study (PMID: 40748423)
