Boron Supplements Boost Testosterone and Fight Inflammation
Quick Summary: A 2011 study tested how taking boron—a mineral found in foods like nuts and fruits—affects hormones and inflammation in healthy men. Taking 10 mg daily for a week raised free testosterone levels by 28% and lowered estrogen, while cutting inflammatory markers like CRP and TNF-α. This is the first human study to show boron can quickly increase free testosterone, suggesting it might help with hormone balance and reducing body-wide inflammation.
What The Research Found
Researchers looked at how boron changes key hormones and inflammation signals in the blood. Here's what they discovered in simple terms:
- After 6 hours of one dose (10 mg):
- Sex hormone-binding globulin (SHBG)—a protein that locks up testosterone—dropped by 10%. This means more testosterone stays "free" and active in the body.
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Inflammatory markers fell: High-sensitivity CRP (a sign of body-wide inflammation) decreased by 37%, and TNF-α (a protein that triggers inflammation) dropped by 18%.
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After 7 days of daily doses (10 mg each):
- Free testosterone jumped 28% (from about 11.6 to 14.8 pg/mL), helping with energy, muscle, and mood.
- Estradiol (a form of estrogen) fell 39% (from 34.5 to 21.1 pg/mL), which might balance hormones.
- Other boosts included dihydrotestosterone (DHT, linked to hair and prostate health), cortisol (stress hormone), and vitamin D (for bones and immunity).
- All three main inflammatory markers (CRP, TNF-α, and IL-6) were lower than at the start, pointing to less overall inflammation.
Boron levels in the blood rose fast after taking it, showing the body absorbs it quickly. These changes happened without any major side effects reported.
Study Details
- Who was studied: Eight healthy adult men—no details on their ages or body sizes, but all were in good health with no known issues.
- How long: Short-term testing over one week, with close monitoring on the first two days (every 2 hours for 6 hours) and a check on day 7.
- What they took: A single 10 mg capsule of boron with breakfast on day 1 for the quick effects, then one 10 mg capsule daily for a full week. They started with a fake pill (placebo) on day 0 to compare.
The study compared each man's own blood results over time, not against a separate group.
What This Means For You
If you're a man interested in natural ways to support testosterone or ease inflammation (like from exercise or stress), this study hints that 10 mg of boron daily could help. Free testosterone supports muscle building, fat loss, and better mood—think more energy for workouts or daily life. Lower inflammation might mean less joint pain or faster recovery.
- Everyday sources: Get boron from foods like almonds, avocados, or prunes before supplements.
- Who might try it: Active guys or those over 30 noticing low energy; always chat with a doctor first, especially if you have hormone issues.
- Real talk: Effects kicked in fast (hours) and built over a week, but this isn't a magic fix—combine with diet and exercise for best results.
Start low if supplementing, and track how you feel.
Study Limitations
This research has some gaps that mean we can't apply it to everyone yet—here's what to watch:
- Tiny group: Only 8 men, so results might not hold for women, older folks, or larger crowds.
- No full control: They compared to a single placebo day, but no ongoing fake-pill group to rule out other influences like diet.
- Super short: Just 7 days—no info on longer use or if effects last.
- Missing details: No ages, weights, or starting boron levels shared, and men took pills at home without checks for skipping doses.
- Not blinded: Participants knew when they got real boron, which could bias feelings or results.
Bigger studies are needed to confirm if boron works the same for you. Don't swap it for medical advice—see a pro for hormone or inflammation concerns.
Technical Analysis Details
Key Findings
The study found that acute (6-hour) and chronic (7-day) boron supplementation significantly altered plasma steroid hormones and inflammatory biomarkers in healthy males. Key results included:
- 6-hour supplementation: Decreased sex hormone-binding globulin (SHBG) by 10% (p < 0.05), high-sensitivity C-reactive protein (hsCRP) by 37%, and TNF-α by 18% (p < 0.05 for both inflammatory markers).
- 7-day supplementation: Increased free testosterone by 28% (p < 0.05), decreased estradiol by 39% (p < 0.05), and elevated dihydrotestosterone (DHT), cortisol, and vitamin D levels. All inflammatory biomarkers (hsCRP, TNF-α, IL-6) were reduced compared to baseline.
This study is the first to report acute boron-induced increases in free testosterone in humans, suggesting potential hormonal and anti-inflammatory benefits.
Study Design
This was an observational study with repeated measures involving 8 healthy male volunteers (age and BMI unspecified). Participants attended the lab on three occasions:
1. Day 0: Placebo ingestion with breakfast, followed by blood collection every 2 hours for 6 hours.
2. Day 1: 10 mg boron ingestion with breakfast, blood collection every 2 hours for 6 hours.
3. Day 7: Blood collected at 8:00 A.M. after daily boron supplementation (10 mg/day).
No control group was included, and outcomes were compared within subjects across timepoints.
Dosage & Administration
- Acute dose: 10 mg of boron administered as a single capsule with breakfast on Day 1.
- Chronic dose: 10 mg/day for 7 days, self-administered with breakfast.
Boron was delivered in capsules, with plasma concentrations measured to confirm bioavailability.
Results & Efficacy
- Plasma boron: Increased significantly after both acute (6-hour) and chronic (7-day) supplementation.
- Hormonal changes:
- Free testosterone rose from 11.6 pg/mL (baseline) to 14.8 pg/mL (Day 7, p < 0.05).
- Estradiol decreased from 34.5 pg/mL to 21.1 pg/mL (p < 0.05).
- DHT, cortisol, and vitamin D levels increased at 8:00 A.M. on Day 7.
- Inflammatory markers:
- hsCRP dropped from 2.8 mg/L to 1.75 mg/L (6-hour, p < 0.05).
- TNF-α decreased from 2.2 pg/mL to 1.8 pg/mL (6-hour, p < 0.05).
- IL-6 levels were not quantified but noted to decline.
Limitations
- Small sample size (n=8) limits statistical power and generalizability.
- Lack of control group: Placebo comparisons were only within the same individuals across days.
- Short duration: Effects beyond 7 days were not assessed.
- No blinding or randomization: Introduces potential bias.
- Limited demographics: Age, BMI, or baseline boron status were not reported.
- Self-administered supplementation: Compliance could not be verified.
Clinical Relevance
These findings suggest that daily boron supplementation (10 mg) may enhance free testosterone levels and reduce systemic inflammation in healthy men. However, the lack of a control group and small sample size warrant caution in interpreting results. The observed hormonal shifts could theoretically support muscle metabolism or hormone balance, while reduced hsCRP and TNF-α align with anti-inflammatory effects. Practical use should consider the short-term nature of the study and the need for replication in larger, diverse populations. Users should consult healthcare providers before long-term use, as cortisol elevation may have implications for stress response or immune function.
Note: This analysis is specific to the 2011 study (PMID: 21129941) and does not incorporate external research.
Original Study Reference
Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines.
Source: PubMed
Published: 2011
📄 Read Full Study (PMID: 21129941)